Assessment of Plasma Levels of Urate and Lipid Profile among Sudanese Patients with Type 2 Diabetes

Abstract

A cross-sectional study conducted during the period from March 2011to May 2011, compared the plasma levels of total cholesterol, triglycerides, high and low density lipoproteins, urate and HbA1c of 52 Sudanese patients with type 2 diabetes mellitus as a test group and 30 apparently healthy (non-diabetic) as a control group. Participants in this study were from Jabir Abu Elez diabetic center in Khartoum state, Sudan. The plasma levels of total cholesterol, triglycerides, high and low density lipoproteins, and urate were measured using commercial reagent kits from Biosystem Company, whereas HbA1c was measured using a semi automated method. The means of the plasma levels of total cholesterol, triglycerides, low density lipoproteins, urate, and HbA1c% of the diabetic group was significantly raised when compared to the control group. The mean of the plasma levels of high density lipoproteins of the diabetic group was significantly reduced when compared to the control group. iii In the diabetic group the plasma levels of total cholesterol, triglycerides, low density lipoproteins, urate and HbA1c show weak positive correlations with the duration of diabetes and the body mass index, whereas the plasma level of high density lipoproteins shows a negative correlation with the duration of diabetes and the body mass index. From the results of this study, it is concluded that; diabetes mellitus is associated with high plasma levels of total cholesterol, triglycerides, low density lipoproteins, urate, and HbA1c and low plasma levels of HDL-c. In addition, there are weak correlations between the plasma levels of total cholesterol, triglycerides, high density lipoproteins, low density lipoproteins, urate and HbA1c with the duration of diabetes and body mass index.