Assesment of Thyroid Hormones level Among Sudanese Womenwith Polycystic Overy Syndrome (Astudy in Khartoum state)

Abstract

Back ground:Thyroid disease and polycystic overy syndrome are of the most common endocrine disorder in general population ,although the etiopathogenesis of the thyroid disorder and PCO is completely different.The aim of study to evulate the thyroid hormones among Sudanese women with polycystic overy syndrome. Materials and Methods:In cross sectional case control study 50 women with newly diagnosied polycystic overy syndrome and 50 healthy apparently control were enrolled (match age).samples were collected in period between Febraury to May 2017 from Elsir Abo Alhassan Center for Infertility in Khartoum state .The clinical data were obtained and serum TSH,serum TT4 and serum TT3 level were measured using ELISA technique and the results were analysed using Statistical Pakage for Social Science (SPSS)computer programe. Results:serum TSH ,serum TT4 and serum TT3 were insignificant differ between polycystic overy syndrome group versus control group Mean +SD For TSH = (2.37+1.68) versus control (2.09+0.88) p.value =0.2 , For TT4 =( 95.3+34.0) versus control ( 95.0+22.0) p value =0.9 ,For TT3 = (1.69+0.70) versus control 1.56+0.74 p.value =0.3 .However body mass index was significant increase between bilateral polycystic overy syndrome and unilateral polycystic overy syndrome group p.value=0.04 .Also the result showed that there were correlation between BMI of PCO women and level of TSH (r=0.316 p.value=0.026).The frequency of thyroid disease, was 14% hypothyrodism and 2% was hyperthyroidism. Conclusion:the study concluded that there were insignificant different in thyroid hormone level among polycystic overy syndrome compared to control group and the frequency of thyroid disease was 14% hypothyrodism and 2% hyperthyroidism.