Preparation of Some 1,4-dihydropyridine Derivatives

Abstract

In the present work a group of nine new 1,4-dihydropyridinederivatives(1,4-DHPs) were synthesized by the reaction between thedifferent aldehydes and amines with ethyl acetoacetate. The selection of these compounds was based upon molecular modeling concept in which ACD/lab program was utilized. Physicochemical properties of a set of 25 compounds of a family of 1,4-dihydropyridine derivatives were obtained. The synthetic design of these compounds was achieved through retrosynthetic analysis. The reaction progress for all synthetic compounds was checked by (TLC) technique, and the structuresof the synthesized compounds were confirmed by IR Spectral data.