Estradiol and Cholesterol level among Females with Polycystic Ovarian Syndrome in Khartoum State

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disease in women, characterized by heterogeneous presentation of hyperandrogenism, ovulatory dysfunc¬tion, and polycystic ovarian morphology (PCOM). This study was carried out to assess plasma levels of cholesterol and estradiol among female with polycystic ovarian syndrome (PCOs). Forty clinically diagnosed polycystic ovarian syndrome (PCOs) in the period between February to May 2017,were chosen randomly from Alsir Abu Hassan Center for Fertility in Khartoum State, and forty apparently healthy individuals as control group, to evaluate the plasma levels of cholesterol and estradiol .Plasma estradiol was measured by using ELISA machine and cholesterol measured by BS-380 chemistry analyzer and results were analyzed using Statistical Package for Social Science (SPSS), computer programmed version 11.5. Anti-Müllerian hormone (AMH) used for the diagnosis of PCOs and when it is levels in the patients compared to the control group. (Mean±SD: 10.6±5.92 versus 1.4±0.22) ng/ml respectively with P.Value 0.000. The study showed that, the mean plasma levels of cholesterol was significantly increased in PCOs female patients. (Mean±SD: 207.6±33.4 versus112±33.4 mmoL /L) respectively with P.vale 0.000. Also the finding of this study showed that, estradiol levels were insignificant difference in PCOs compared with control group. (Mean±SD: 86±39versus 101±38.6 pg/ml) respectively with P.Value 0.086. Person correlation showed that, there was insignificant negative correlation between cholesterol level and the level of estradiol(r= -0.123, P.Value = 0.448). It is concluded that: the plasma levels of cholesterol is higher in PCOs Female patients.