Development Of Method Of Analysis for Paracetamol Tablet

Abstract

This research for comparison of pharmaceutical product from two deferent companies using two different method of analysis (HPLC and UV) then compare between two methods by obtained the sensitivity and the accuracy of results. The results shown that the content of paracetamol in sample one and two respectively by using UV 98.1%, 97.9% and the content for the two sample when using HPLC 99.8%, 100.3% respectively. From the observed results HPLC sensitive method more sensitive and accurate than UV method, this refer to using separation and determination analytical method in the same time, the excipients had been separated from the active ingredient that was been analyzed, then determine the active ingredient on the opposite when using UV method the active ingredient and excipients was not separated. Also HPLC method used a little quantity of sample used for quntitive , qualitative analysis HPLC method was found to be adequate and it should there for be used to obtaing accurate date.