Assessment of Plasma Levels of TMagnesium , Zinc and HeamoglobinA1c% in Sudanese with Type 2 Diabetes Mellitus.

Abstract

This is a case-control, hospital-based study, conducted during the period from July 2011 to March 2013 in Soba hospital, Khartoum state, Sudan. 200 Sudanese patients with type 2 diabetes mellitus and 50 healthy controls were involved in this study. The diabetic group and the control group were matched for age and gender. The objective of this study was to assess the plasma levels of Mg, Zn and Hb A1c% in Sudanese with type 2 diabetes mellitus in comparison with apparently healthy volunteers. Mg, Zn and Hb A1c were assayed for each participant using standard biochemical methods. In this study, the means of the plasma levels of Magnesium and Zinc of the diabetic group were significantly reduced when compared to the control group, whereas the means of the blood levels of Hb A1c%of the diabetic group were significantly raised when compared to the control group. The study showed a significant weak negative correlation between the plasma levels of Magnesium and Hb A1c% (r= -0.31, p= 0.00). And also showed insignificant very weak negative correlation between the plasma levels of Zinc and Hb A1c% (r= -0.08, p= 0.42) .From the results of this study it is concluded that, the plasma levels of Magnesium and Zinc are significantly reduced in Sudanese with type 2 diabetes mellitus compared to healthy controls. The plasma levels of Magnesium have significant negative correlation with Haemoglobin A1c% in the diabetic group.