Assessment of plasma levels of high sensitive c - reactive protein and cholesterol among Sudanese with Type2 diabetes mellitus

Abstract

A case control study was conducted during the period from March 2012 to June 2012 to assess the plasma levels of high sensitive C-reactive protein and cholesterol among Sudanese with type2 diabetes mellitus. Hundred patients with type2 diabetes mellitus were selected as a test group from the Military Hospital and Zenam Diabetes Center in Khartoum state, Sudan. The test group was compared with a control group which included 50 healthy volunteers. Blood specimens were collected from both groups and fasting blood glucose, glycated hemoglobin, total cholesterol and high sensitive C-reactive protein were estimated. Age and gender of the test group were matched with the control group. Spectrophotometeric methods were used for measurement of glucose and total cholesterol. glycated hemoglobin was measured by using NycoCard II device and the high sensitive C-reactive protein was measured by using i-CHROMA device. Statistical package for social science (SPSS version 11.5) computer software was used for data analysis. The results indicated a significant increase in the mean of the plasma levels of high sensitive C-reactive protein of the test group when compared with the control group (3.10 �2.69mg/L) versus (0.47� 0.12 mg/L) (p=0.000), and a significant elevation in the mean of plasma levels of high sensitive C-reactive protein in diabetic patients with hypertension when compared with the mean of those without hypertension (7.03� 1.62 mg/L) versus (1.65� 1.06 mg/L) (p=0.000).Also there was a significant elevation of the plasma levels of high sensitive C-reactive protein in females with type2 diabetes mellitus when compared with the mean of diabetic males (3.65�2.92mg/L) versus (2.53�2.34mg/L) (p=0.037). The results indicated a significant, strong positive correlation between high sensitive C-reactive protein in type2 diabetic patients and fasting blood glucose (r=0.91, p=0.000), glycated hemoglobin (r=0.88, p=0.000), body mass index (0.91, p=0.000) and the total cholesterol (r=0.78, p=0.000).