TSH and T3 Levels among Sudanese ChildrenWithSickle cell Anemia in Heglig City

Abstract

Endocrine dysfunction in hematological disease like SCD can be encountered commonly and at early ages, ischemia and inflammatory mediators are proposed reasons for endocrine dysfunction, the etiology of thyroid dysfunction in SCD is not clear. This is case control study conducted during the period from April to December 2016 in Heglig cityHeglig hospital to determine the levels of TSHandT3 among Sudanese childrenwith sickle cell anemia, the levels of TSH andT3 was estimated by using mind ray instrument. The study includes 80 subjects, 43 of them were sickle cell anemia children, 7 of them were sickle cell trait, and 30 of them were control group. Statistical analysis was done by using SPSS ,and the results reveled asignificantdecreased in means of TSH level in sickle cell anemia children ,(0.87±0.79) when compared to trait group(4.0±3.8)with(p. value=0,000).The results alsoreveled ,The mean of TSH level was insignificance difference in sickle cell anemia children (0.87±0.79) when compared to control group (0.81±0.66) with (p. value=0,6).The study results alsoreveledasignificant increased of TSH level in sickle cell trait (4.0±3.8)when it compared to control group (0.81±0.66) with(p. value=0.000).The study results alsoreveled insignificant difference in mean of T3 level in sickle cell anemiachildren,(0.64±0.2)whencomparedtotrait group(0.8±0.3)with(p. value=o.1).The study results alsoreveled insignificant difference in mean of T3 level in sickle cell anemia children (0.64±0.2) when it compared to control group (0.66±0.24) with (p. value=0.7).and The results reveled insignificant difference in mean of T3 in sickle cell trait, ( 0.8±0.3) when it compared to control group(0.66±0.24)with (p. value=0.1).The study results alsoreveled, in significant difference in mean of TSH Level in sickle cell anemia children male(0.87±0.7)in compared to female children group(0.82±0.84)with(p. value=0.8),the results reveled insignificant difference in mean of T3 level in sickle cell anemia male,(0.59±0.2)when it compared to female group (0.82±0.89)with(p. value=0.3).The study results reveled insignificant positive correlation(r=0.038.p.value o.8)between duration of sickle cell anemia and TSH among Test group. The study results also reveled insignificant negative correlation (r=-0.17.p.value.0.2) between duration of sickle cell anemia andT3 among test group. The study observed sickle cell anemia had no affect on the levels of serum TSH andT3, also there were no affect on the levels of TSH and T3according to gender, also duration of sickle cell anemia increase the level of TSH and decrease level of T3.