Determination of Platelets Count and Indices as Predictive Markers for vascular Occlusion among Hypertensive Sudanese Patients at Military Hospital - Omdurman

Abstract

This was an analytical case control study conducted in Military Hospital Omdurman aimed to measure the changes in platelet count and platelet indices (PDW, MPV, and P-LCR) in Sudanese patients with hypertension. Platelet counts and indices are potentially useful markers for Platelet activation and in early diagnosis of thromboembolic diseases and play a critical role in the pathophysiology of thrombotic events, myocardial infarction and peripheral vascular disease. The study was conducted on 70 patients with age range (30-85) of both sexes with hypertension and 70 subjects as control group. Five mls of blood sample was collected in container contain EDTA anticoagulant. Platelet counts, platelet distribution width (PDW), mean platelet volume (MPV) and platelet large cell ratio (P-LCR) was measured by using an automated blood cell counter (Sysmex KX-21N). Data collected was analyzed by using Statistical Package for Social Science (SPSS) computer program version 11.5. There was no statically significant difference among hypertensive patients in platelet count (294 ±103 vs 269 ±74×109/L) p.v 0.1, PDW (11.7 ±1.9 vs 11.8±1.6FL) p.v 0.6, MPV (9.6 ± 0.9 vs 9.7± 1.2 FL) p.v 0.5 and P-LCR (22.3±7.2 vs 22.5±6.4 %) p.v 0.8 respectively. There was statically significant correlation between platelet count, PDW, MPV, P-LCR with p.v< 0.01 in cases and controls. Negative correlation was observed between platelet count and PDW, MPV and P-LCR. Compared with Positive correlation was observed between PDW, MPV and P-LCR. The study concluded that no significant effect of hypertension on platelet count and indices. There was correlation between platelet counts, PDW, MPV, and P-LCR.