Immunohistochemical Expression of E cadherin in Renal Tumors

Abstract

This is analytical retrospective case control study conducted at Ibn Seina Hospital and Sudan University of Science and Technology-College of Medical Laboratory science during the period from January to May 2016. The study aimed to detect E cadherin in renal tumors among Sudanese patients using immunohistochemical method. 72 paraffin blocks samples were collected from patients previously diagnosed as renal tumors (54 diagnosed as malignant renal tumors, 18 as benign renal tumors). Of whom 30 (41.6%) were male and 42 (58.4%) were female. Their ages ranged between 21 to 85 years with mean age 55 year. From each block one section was cut (3µm) by using rotary microtome to detect E cadherin in renal tumors. Data was analyzed using SPSS version 20 computer programs; mean, frequency and chi square were calculated E cadherin was positive in 43 (59.7%) samples, while 29 (40.3%) samples were negative. From positive results, 17 (23.6%) in benign renal tumors, while 26 (36.1%) in malignant renal tumors with significant differences between E cadherin expression and renal tumors (P = 0.001). Positive result in malignant renal tumors distributed as follow, 11 (20.4%) in papillary RCC, 7 (13%) in non classified tumors, 6 (11.1%) in chromophobe RCC, and 2 (3.7%) in clear cell RCC with significant differences between E cadherin expression and subtypes of malignant renal tumors (P = 0.000). On the basis of these results the study concluded that, there is a relation between E cadherin expression and benign renal tumors. There is a relation between E cadherin expression and subtypes of malignant renal tumors, strongly expressed in chromophobe RCC and papillary RCC.