Determination of Prothrombin Time, Activated Partial Thromboplastin Time and plasma fibrinogen level among Hypertensive, Diabetic and Normal pregnant women at third trimester in Khartoum State

Abstract

This was analytical case –control study conducted in Khartoum State during the period from September to December 2015. The aim of this study was to compare the prothrombin time, activated partial Thromboplastin time and plasma fibrinogen level between hypertensive pregnant, diabetic pregnant, normal pregnant and control group. A total of 120 consecutive females were enrolled;30 pregnant with hypertension, 30 pregnant with diabetes, 30 normal pregnant and 30 from healthy females (control group). 2.7 ml of blood samples were collected in 3.2% tri-sodium citrate after informed consent taken from each female . Coagulation profile was estimated using Dia med coagulometer. The mean of age in pregnant with hypertension was (28.97±6.14 years), pregnant with diabetes was (31.03±5.55 years),normal pregnant was(26.97±6.80 years) and control group(28.03±7.44 years).PT was significantly decreased in hypertensive pregnant (13.82±2.10 sec) and diabetic pregnant(12.61±1.37 sec) compared to control group(15.48±2.65sec)(p.value 0.010) , (p.value 0.000 )respectively, and insignificantly difference between normal pregnant (15.01±1.94 sec) and control group (p.value 0.434) and significantly decreased in pregnant with hypertension and pregnant with diabetes compared to normal pregnant (p.value 0.029) (p.value 0.000) respectively, significantly decrease in diabetic pregnant compared to hypertensive pregnant(p.value 0.026).APTT was significantly decreased in hypertensive pregnant(34.28±3.48 sec) and diabetic pregnant (35.60±4.83 sec) compared to control group(40.39±4.79sec)(p.value 0.000 for both) and insignificantly difference between normal pregnant(40.88±3.82 sec) and control group (p.value 0.491) and significantly decreased in pregnant with hypertension and pregnant with diabetes compared to normal pregnant (p.value 0.000 for both) and insignificant difference in diabetic pregnant compared to hypertensive pregnant(p.value 0.236).fibrinogen level was significantly increased in hypertensive pregnant(520.23±68.05 mg/dl), diabetic pregnant(548.83±99.71 mg/dl), normal pregnant(398.23±38.39 mg/dl) compared to control group(268.37±59.67 mg/dl) (p.value 0.000 for all) and insignificant difference between hypertensive pregnant and diabetic pregnant(p.value 0.116) and significant increase in hypertensive pregnant and diabetic pregnant compared to normal pregnant (p.value 0.000 for both). This results analyzed by the program of Statistical Package for Social Science version 16. In conclusion fibrinogen was significantly increased in hypertensive pregnant, diabetic pregnant and normal pregnant so measurement of PT , APTT and plasma fibrinogen level may be predictor of thrombosis in pregnancy.