Assessment of Serum Creatine Kinase, Aspartate aminotransferase and Alanine aminotransferase Activity Levels in Sudanese Patients with Hypothyroidism in Khartoum State.

Abstract

Thyroid gland disorders are the most abundant endocrine disorders after diabetes mellitus, and the most common disorders are hypothyroidism, hyperthyroidism and Goiter. This is a case control study was done in Khartoum State during June- September 2015, to assess the effects of thyroid disorders in CK, ALT and AST activity levels. Thirty hypothyroidism patients as test group and 30 health subject as control group (age and genders was matched) were enrolled in this study, blood samples were collected from participants and CK, AL T, AST activities were measured in serum samples by using spectrophotometer. Statistical analysis was done by using SPSS, the results showed a significant elevation in CK, ALT, and AST activities in patient with hypothyroidism when compared with control group (P. Value: 0.00, 0.04, and 0.00 respectively). The results also showed that the treatment of hypothyroidism returns abnormal activity levels of CK, ALT, AST to normal compared to patients who were not under treatment (P. value: 0.00, 0.012 and 0.007 respectively). CK activity levels have a significant strong negative correlation with T3 (P. value 0.00, r= -0.788) and ALT activity levels have a significant moderate negative correlation with T3 (P. value = 0.024, r = -0.411) while AST activity levels has an insignificant negative correlation (P.value = 0.187, r = -0.248) T4 has an insignificant correlation with CK, ALT, and AST activity (P.value = 0.592, r= -0.102), (P.value = 0.989, r = -0.003), (P.value = 0.614, r= 0.096) respectively. Also TSH has an insignificant correlation with CK, ALT, and AST (P.value= 0.749, r = -0.61), (P.value = 0.445, r = -0.145), (P.value = 0.547, r = 0.114) respectively. In conclusion: Thyroid disorders specially hypothyroidism affect CK, ALT and AST activity levels, mainly CK which one of the cardiac markers and CK and ALT levels elevated in order to T3 decreasing.