Determination of Complete Blood Count in Diabetic type 2 Nephropathy Patients¬-Khartoum State

Abstract

This is case controlstudy is conducted during the period from May to October (2015) in Jabir Abualiz Center and AlsafaHospital, to determine the CBC of type 2 diabetic patients with nephropathy. One hundred and fifty blood samples were collected from 100 Diabetes Type 2Nephropathypatients as groupA, 25 with type 2 diabetes mellitus as group B and 25 samples from healthyindividuals as groupC. Three ml of venous blood was collected from each participate in Ethylene Diamine Tetra Acetic Acid (EDTA) anticoagulant test tube and used to determine the Hb, PCV, RBCs count, red cell indices, WBCs count, differential and platelets count in all study groups (A, B, C).Complete blood count was measured by automated hematological analysis (Sysmex KX N21) and the data obtained were analyzed using software program statistical package of social science (SPSS).The study revealed that diabetic nephropathy prevalence more in males (79%).The results of thisstudy showedthat therewasa significant decrease many hematological parameterindiabetictype 2 nephropathy patients (group A) compared to group B and C.Hb(11.9g/dl±1.27-13.4g/dl ±1.07-14.1 g/dl ±1.08). RBCs count (4.5×1012 /l ± 0.50 - 5.03 ×1012 /l ± 0.38 -4.9×1012 /l ± 0.44). PCV (35.8% ± 4.08 - 40.2 % ± 3.44 - 41.9% ± 3.37). MCV (82.2 fl ± 3.66 - 84.1fl ± 4.57- 84.6fl ± 3.91) respectively. Significant decrease in MCH and MCHC in group A in compared to group C. The comparison between group C and B showedsignificant decreasein Hb, MCH and MCHC. Showed significant increase in TWBCs count and neutrophil count of group A in compared with group C, (6.9×109 /l±1.99 - 5.9×109 /l ±1.16), (4.1×109 /l ±1.80-3.2×109 /l ±1.16) respectively.So, the study concluded that Hb,RBCs count, PCV and RBCs indices significant decreased in Diabetic Type 2 Nephropathypatients compared to diabetic type 2 patients and healthy individual group.Also the TWBCs and neutrophil count are significant increase in diabetic type 2 nephropathy.