Detection of Lupus Anticoagulant Antibodies among Sudanese Women with Habitual Abortion

Abstract

This study is a cross sectional study, conducted in Khartoum state during the period from December 2013 to July 2015 to determine lupus anticoagulant among Sudanese women with habitual abortion.140 patients with three or more habitual abortion and 60 healthy pregnant women without history of abortion were selected as control group.The age was ranging between 17 -45 year in both groups. Patients and control groups were screened for the presence of LA and Fibrinogen level by using coagulometer (Coatron M2), ACA by using enzyme linked immunosorbent assay (ELISA) . The results were analyzed by using program Statistical Packages of Social Sciences version 21 (SPSS program )and express as means ,The results obtained showed that the means of LA, Fibrinogen level and ACA for patients (61.4 ± 21.6 sec),( 265.28 ± 118.9 mg/100mL) and (242.5 ± 124.3 u/mL) respectively .The mean of LA, Fibrinogen level and ACA of control group was (36.422 ± 4.6 sec ),( 255.1 ± 68.5 mg/100mL) and ( 40.4 ± 4.51 u/mL ) respectively .The study showed that 37 of the patients (26.4 %) had lupus anticoagulant, the geographical distribution of the 140 patients ,23 (16.4%) were from South Kurdfan. The study concluded that the presence of LA was significantly associated with habitual abortion .The current study recommends measuring of LA and ACA in all women with 3 or more consecutive spontaneous abortion South Kurdfan should be investigated in particular.