Evaluation of High Sensitive C reactive Protein among Adult Smokers in Khartoum State

Abstract

Cigarette smoking is a classical and a major risk factor in the development of several diseases such as cardiovascular diseases. A cross sectional study conducted at the February and March 2015 aim to evaluate the effect of cigarette smoking on High Sensitive C Reactive Protein level in Sudanese smokers. In this study 175 subjects were chosen for determination of plasma High Sensitive C Reactive Protein. Fifty were heavy smokers, fifty were light smokers, Twenty five were ex-smokers the other fifty were apparently healthy and not smoker subjects servers as control group for the comparison. All the tests and control group are fall within the middle age (29 years). Plasma High Sensitive C Reactive Protein was estimated by Cobas C 311 automated chemistry analyzer and data analysis done by using t-test and Pearson correlation, by using the computer program Statistical Package for Social Sciences. Analysis showed that there is a significant increases in the mean value of High Sensitive C Reactive Protein in smokers when compared with control group with (P-value 0.013) and the mean values of High Sensitive C Reactive Protein in heavy and ex-smokers was significant high when compared to control with (P-value 0.000) (P-value 0.025) respectively. While showed no statistical significances difference in High Sensitive C Reactive Protein level in light smokers when compared to control with (P-value 0.402). There was no statistical significant difference in High Sensitive C Reactive Protein level in current smokers with ex-smokers with (P-value 0.995). However, There was a positive correlation between High Sensitive C Reactive Protein and smoking duration (r= 0.281, p =0.006). The study concluded that plasma High Sensitive C Reactive Protein is elevated in cigarette smokers individual and elevation of hs-CRP is depending on smoking type and duration.