Abstract:
Breast cancer comprises 10.4% of all cancer incidence making it the
second most type of non skin cancer and the fifth most common cause of
cancer death. Breast cancer is about 100 times more common in women
than in men, but survival are equal in both. it constitutes 13-35% of all
female cancer. The aim of this study is to determined the Complete Blood
Count in Sudanese females with breast cancer under treatment with
( Chemotherapy, Radiation or mastectomy) .
This is a hospital based case control study conducted to measure complete
blood count in females with breast cancer, 100 blood sample were
collected from females with breast cancer compared to 20 healthy females
The sample was collected in EDTA anti coagulated and tested to measure
Complete blood count using automated cell counter ( sysmax KX 21) to
find out ; the hemoglobin concentration (Hb), Red blood cells count
(RBCs) , Packed cell volume (PCV) ,RBCs indices , White blood cells
(WBCs) count and Platelet count. blood film were prepared to evaluate cell
morphology.
The result of this study showed that there was decrease in mean of Hb
(7.66) , PCV (31.98), MCV (83.03), MCHC (27.03) and PLTs (295.88)
while there were normal value in the mean of WBCs count. also, the
result showed 65% of patients were anemic 27% was Microcytic
Hypochromic and 35% was Normocytic Normochromic. the result showed
that the mean value of Hb and PLTs in patients receiving chemotherapy
was significantly reduced with P-value (0.00) while the WBCs was not
affected . The result showed a significant reduction in Hb , PCV , MCV
and PLTs in females with breast cancer according to breast feeding.
The study concluded that the chemotherapy has a significant effect on Hb
and PLTs in patients with breast cancer while WBCs was not affected .
Also, there is no significant difference in Hb, WBCs and PLTs according
to mastectomy of breast.
