Abstract:
The objective of thisstudy was to assess serum anticardiolipin and serum
progesterone in Sudanese women with recurrent miscarriage in comparison with
apparently health women.
A cross – sectional ,hospital based study was conducted during the period from
March 2011 to April 2012 , in Khartoum state . 86 blood samples were collected from
woman with recurrent miscarriage (case group), and 86 blood samples from woman
with apparently healthy ( control group) ,age were matched in both groups . serum
anticardiolipin and serum progesterone were measured using ELISA and
commercial kits from EROIMMUNE and DRG Company .
The results showed a significant increase in means serum anticardiolipin antibodies
(ACL) in patient group (5.554± 3.421 ng/dL) when compared with the control group
(1.197± 1.111 ng/dL) P value 0.000 .There were significant decrease in serum
progesterone among patient group (4.419± 2.932ng/dL) when compared with the
control group(32.01± 2.939ng\dL) P .value 0.000. There were significant increase in
means serum anticardiolip in case group group (5.554± 3.421 ng/dl) when compared
with both control groups, control pregnant group(1.23± 0.999 ng/dL) P .value 0.001,
and control non pregnant group (1.161± 0.112 ng/dL) P value0.000. There were
significant decrease in serum progesterone in the patient group (4.419± 2.932ng/dL)
when compared with both controls , control pregnant group women (20.042± 17
ng/dL) P value 0.000,and control non pregnant group (8.06± 5.80ng\dL) P
value0.000 .There was significant positive correlation between serum anticardiolipin
and serum progesterone(r=0.245,p=0.02). There was insignificant positive correlation
between the number of miscarriage and serum progesterone( r=0.122, p=0.2) ,also
there was insignificant positive correlation between the serum anticardiolipin and the
number of miscarriage(r=0.151, p=0.166 ) .Thefrequency of positive anticardiolipin
among case group was 11.6 % while it was 1.2% among control group .
Conclusion: There were significant increase in serum anticardiolipin ,and significant
decrease in serum progesteroneof the case group when compared to the control
group. There was significant positive correlation between serum anticardiolipin and
serum progesterone .11.6%had appositive anticardiolipin case study while 1.2% in
control group.
