Abstract:
This study was conducted in Khartoum State during the period from April to October
2013; its community based case control study.
Objectives of the study: the main aim of the study is to assess the thyroid hormones
among Sudanese smokers in Khartoum State .
Materials and methods : Eighty plasma samples were collected from healthy
heavy Sudanese smokers at different ages . In addition to 50 plasma samples from
healthy non smokers at different ages for comparison, of thyroid stimulating
hormone (TSH) , thyroxine (T4) and tri-iodothyronine (T3) . The level of thyroid
hormones in the study was estimated by Omega pathozyme method using Enzyme
immunoassay.
Results : the study showed significant increase in thyroxine (T4) , tri-iodothyronine
(T3) level in healthy heavy smokers when compared with the control group .( 146.8
±39.0 versus 96.7 ± 25.4 ng /ml , 2.36 ± 0.76 versus 1.96 ± 0.59 nml/ml
respectively ) , ( p ≤ 0.05 ) , with significant decrease in Thyroid stimulating
hormone (TSH)
( 1.68 ± 1.11 versus 2.21 ± 0.99 μIU/ml respectively ), ( p ≤ 0.05 ) , The
study recorded significant correlation between thyroid hormones and both age and
the duration of smoking
( p > 0.05 ) .
Conclusion : The study revealed significant increase in thyroxine (T4) , tri-
iodothyronine (T3) with significant decrease in thyroid stimulating hormone (TSH)
in healthy smokers.