Abstract:
This study was carried out with the participant of 81 patients
suffering hypothyroid disease. In which 25 were sub clinical
hypothyroidism and 56 were overt hypothyroidism. Patients with
other serious diseases such as liver and kidney and cardiac diseases
were excluded. Other 18 apparently healthy subjects with no signs of
thyroid hormone disease were also participated to served as control.
Serum total cholesterol, triglycerides, Creatine kinase, LDL-
cholesterol and HDL- cholesterol, TSH, T3, T4 were measured in
both hypothyroidism patients as well in euthyroid control subjects.
The findings of this study revealed that the majority of hypo
thyroid patients presented with clear signs and features of
hypothyroidism mainly fatigues, tiredness, etc. and all patients
presented with average ages between 35 – 36 years, and females are
predominated.
The study reverled that TSH hormone in general was
significantly highly elevated in both hypothyroidisms compared with
control. In sub clinical hypothyroidism elevation in TSH level of
about 12- fold over control was noticed 15.8 mu / L versus 1.3 mu /L
, while in overt hypothyroidism, about 31- fold increased was
observed. But for T3 and T4, the situation is differ. There was no
remarkable changes in case of T3 in overt hypothyroidism patients
and in sub clinical hypothyroidism. But In case of T4, a significant
decrease in T4 was found in overt hypothyroid but remained within
the normal value in sub clinical hypothyroidism patients.
The findings obtained from this study also revealed that total
cholesterol and triglycerides were significantly increased over
euthyroid control subjects in both hypothyroid patients. Also LDL-
cholesterol were either borderline high (136 mg/dl) compared with
control in sub clinical hypothyroidism or high (173mg/dl) in overt
hypothyroidism.
In case of HDL- cholesterol, the levels were slightly reduced
in overt hypothyroidism groups compared with control (44.6 mg/dl
versus 49.5 mg/dl) but in subclinical hypothyroid HDL remained
unchanged in comparison to control (48.3 versus 49.5 mg/dl).
CK in overt hypothyroidisms was significantly elevated
(145mg/dl versus 59 mg/dl for control) and remained within normal
range for subclinical hypothyroidisms.(78 mg/dl versus 59 mg/dl for
control ) .
In general the results concluded that lipid profile under
hypothyroidism was clearly disturbed in which remarkable increase
in total cholesterol, triglycerides and LDL- cholesterol was evident
in hypothyroid patients and slight decrease in HDL- cholesterol was
also seen. Lipid alteration was return to euthyroid state upon T4-
thyroxin therapy.
The study also may presume that the tendency of LDL- cholesterol
for oxidation may justify it observed elevation in hypothyroid
patients and
antioxidant.
4
– thyroxine replacement therapy was act as
antioxidant