Abstract:
A cross-sectional hospital based study conducted during the period
from october 2008 to october 2010, compared the plasma levels of total
bilirubin, conjugated and unconjugated bilirubin, AST, ALT, ALP, total
protein, albumin, creatinine , and creanine clearance of 101 Sudanese
patients with dengue fever and dengue haemorrhgaic shock syndrome (as
a test group) and 50 apparently healthy volunteers (as a control group).
Participants in this study were from different hospitals in port Sudan,
Sudan. Age and gender of the test group were matched with the control
group. The plasma levels of total protein, albumin, AST, ALT, and ALP were
measured using commercial kits from Biosystem Company, while the
plasma levels of total bilirubin, conjugated and unconjugated bilirubin,
creatinine, and creatinine clearance were measured using commercial
kits from Human Company. All biochemical tests were done using a
spectrophotometer from Biosystem Company.
In patients with dengue infection; the plasma levels of total
bilirubin, conjugated and unconjugated bilirubin, AST, ALT, and creatinine
were raised, ALP, total protein, and albumin were not significantly
changed, whereas creatinine clearance were significantly reduced when
compared to the control group.
In patients with dengue shock syndrome; the plasma levels of total
bilirubin, conjugated and unconjugated bilirubin, AST, ALT, and creatinine
were significantly raised, ALP were not significantly changed, whereas plasma
total protein, albumin, and creatinine clearance were significantly reduced
when compared to those with dengue fever.
The test group, showed insignificant weak negative correlations between
creatinine clearance and the plasma levels of total bilirubin, conjugated and
unconjugated bilirubin, AST, and ALT.
From this study, it is concluded that; in Sudanese patients with dengue
fever and dengue shock syndrome there is impairment of both renal and liver
function, this impairment is more sever in those with dengue shock
syndrome.
