Abstract:
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia,
that can either result from genetic disorders or from defects in insulin
.hormone
This study is performed in Khartoum state during the period from January
.2011 to May 2011
The aim of the study is to compare the sensitivity of C – reactive protein
and cholesterol in detection of early cardiovascular disorders in Sudanese
.with type2 diabetes mellitus
Seventy five blood samples were collected from Sudanese diabetic
patient with type 2 diabetes mellitus, their age range from 30 – 60 years,
and seventy five healthy volunteers as control group for the comparison.
Serum cholesterol was estimated enzymatically with spectrophotometer
(Biosystem 310), and CRP level was estimated turbidmetrically with
.(automation technique (Mindary BS 300
The study observed significant increase in the C-reactive protein level in
the study group of type 2 diabetes mellitus when compared with control
group (4.56 ± 1.51 mg/L) verses (1.57 ± 0.33 mg/L) respectively, (P =
0.00), and the level of CRP is greater in females than in males test group
of type 2 diabetes mellitus (5.7 ± 1.58 mg/L) verses (4.1 ± 1.45 mg/L)
respectively. Significant maximum elevation of C-reactive protein level
was observed during the early period of type 2 diabetes mellitus in
group 2( from 1 year to 5 years) (5.2 ± 1.56 mg/L). In contrast,
cholesterol level reached the maximum level in group 2 (after 20 years
from the onset of type 2 diabetes mellitus). The study observed that there
is no significant correlation between CRP level and duration of type 2
.diabetes mellitus in the study group
In conclusion: CRP is higher in test group of type 2 diabetes mellitus
than in healthy individuals, reached the peak maximum in the first five
level reached the peak maximum after twenty years from the onset of
.type 2 diabetes mellitus
