Abstract:
Thiadiazole compounds are playing an important role in our life, through their
biological activities in various fields, as antibacterial, antifungal, plant activator, and
as pesticides. In this work six compounds as 1,2,3-thiadiazole derivatives were
prepared. In this work carbonyl groups were allowed to condense with ammonia
derivatives of semicarbazide to give imines’ bond. The carbonyl group of
semicarbazide acts as a reactive group in cyclization of the reaction product between
ketonic compounds of semicarbazide (semicarbazone) with thionyl chloride to give
five-membered heterocyclic rings. The compounds were prepared according to a well-
established literature methods and the identities of these compounds were confirmed
by IR, H1-NMR, and MS Spectrometer and T.L.C. analysis. Mechanism of reaction
and appropriate retro synthetic analysis were given and discussed in chapter three.
Detailed spectral (IR, H1-NMR, MS) analysis of the target compounds was given. The
functional groups and protons environment were assigned to the proper absorption
bonds, special emphasis was put upon the carbonyl group stretching vibration in IR.
A variation in the number of peaks, positions and increasing or decreasing in the
values of bonds were noticed according to the various effects, such as resonance
effects, conjugation effects and anisotropic effects.