dc.contributor.author |
Hamid, Hussien Hamid Mohammed |
|
dc.contributor.author |
Supervisor,- Hussain Gad-Elkarim Ahmed |
|
dc.date.accessioned |
2014-01-06T11:50:58Z |
|
dc.date.available |
2014-01-06T11:50:58Z |
|
dc.date.issued |
2009-01-01 |
|
dc.identifier.citation |
Hamid,Hussien Hamid Mohammed.Assessment of Cellular Proliferative Activity in Buccal Mucosa of Toombak Users in El-Obied City/Hussien Hamid Mohammed Hamid;Hussain Gad-Elkarim Ahmed.-Khartoum:Sudan University of Science and Technology,college of Medical Laboratory Science,2009.-69p. : ill. ; 28cm.-M.Sc. |
en_US |
dc.identifier.uri |
http://repository.sustech.edu/handle/123456789/3056 |
|
dc.description |
Thesis |
en_US |
dc.description.abstract |
This is a descriptive prospective study to identify the cellular proliferative
activity by Papanicolaou stain and mean AgNOR counts of the buccal
mucosa of toombak users and non-Toombak Users in brush smears. The
study was conducted in North Kordofan State – El-Obied during the period
from April 2009 to August 2009. The smears were obtained from 200
apparently healthy male individuals, 100 were toombak users (cases) and
the remaining hundred were non-tobacco users (controls), their ages
ranging from 11 to 70 years with a mean age of 26 years. The mean age
for the cases was (27.5 ±11 years), hence, the mean age for the controls
was (24 ±10 years).
All of the cases were identified with keratinization; hence, only one study
subject was identified with keratinization among control group due to
alcohol drinking. Out of the 100 cases, 47 (47%) individuals were
demonstrated with low keratinization and the remaining 53 (53%) persons
were demonstrated with excessive keratinization (P < 0.0001). Higher
proportions of low keratinization were found in duration range less than 10
years while High frequency of excessive keratinization was detected in
duration range more than 11 years. In regard to the age, excessive
keratinization is relatively increased with increasing of age.
In regard to the infections and inflammatory conditions, cases were more
susceptible than controls, erosions and exposure of oral mucosa to
toombak irritation are the major causative factors.
In the measurement of the AgNORs, 26 (26%) of the cases showed
abnormal NOR count.
Statistically, the mean AgNORs counts for the
controls (1.56 ±0.41) was lower than that for the cases (2.35 ±1.6) (P <
0.0001). However, 20 (10%) and 6 (3%) of the specimens showed
excessive and low keratinization respectively (P < 0.03).
These findings support that toombak dipping is a high risk factor for oral
mucosal proliferative lesions and AgNORs and Papanicolaou tests are
used as screening methods for toombak users. |
en_US |
dc.description.sponsorship |
Sudan University of Science and Technology |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Sudan University of Science and Technology |
en_US |
dc.subject |
Toombak-Sudan |
en_US |
dc.title |
Assessment of Cellular Proliferative Activity in Buccal Mucosa of Toombak Users in El-Obied City |
en_US |
dc.type |
Thesis |
en_US |