Abstract:
The evaluation of glomerular filtration rate GFR by using renal Scintigraphy with
enhancement of gamma camera system model (nucline spirit (DHV) variable angle dual
head SPECT and whole body DH -503066-VO ) and Low energy general purpose
collimator, has been carried out among 149 patients of multi renal diseases and 48 as a
control group with age between 20-80 year . The obtained GFR was from an injection of
the sample and control group by Tc-99m\DTPA as 185MBq (5mci). The collected data
was the age versus GFR, weight versus GFR, height versus GFR and the normal GFR, in
addition to the general distribution of the sample based on the gender.
The study shows that: within the control group sample, the male represents 60.41%
relative to the female who were representing 39.58%.
Regarding GFR, the study reveals that: the predominant mean of GFR was 82.5 ml/min
among the age group of 20-30 years old and the maximum GFR was 85.2 ml/min among
the age group of 30-40 years old. While the age group of 40-50 years old have the lowest
GFR which was 76.8 ml/min.
The researchers also found that the relationship between the age and GFR is a inverse
relationship i.e. as the age increases as the GFR decreases, such relationship was
demonstrated by the following equation ( y 0.0393x 84.135 ), where y refer to GFR
in ml/min and x refer to age in years.
The results also reveal that the maximum mean of GFR is 86 ml/min, which is found
among the weight group of 90-100 Kg, while the minimum GFR which is 81.5 ml/min
was among the weight group of 40-50 Kg, indicating that the GFR increases as the
weight increase. And the normal GFR among the Sudanese people in the range of 84 –
85.9 ml/min which fall in the range of standard GFR stated by Jacobsson et al, (1985) in
which they found that the normal mean GFR was 84.75 16.63 ml/min. the general
relationship between the weight and the GFR was deduced to be as follows:
y 0.814x 81.8 where x refer to weight in Kg and y refer to GFR in ml/min. the study
also shows that the common people encountered at hospitals complaining of renal
problems were having the weight between 40-70 Kg.
The analysis of the study also reveals that the height has a poor relationship with GFR
that could be demonstrated in a form of the following equation y 0.2332x 122.43
where y refers to GFR and x refers to height, indicating that as the height increases the
GFR increases.
The ultimate goal of the study is that the normal GFR which has been determine by
gamma camera method is 85.5 14.2 ml\min with an accuracy equal to 85.5% showing
some advantages such as simple achieved accuracy, less time consuming, low radiation
hazards, simplicity and non invasive method relative to Single Injection Two Plasma
methods SITPM which determined by Jacobson in 1985 with an accuracy equal to
84.75 16.63 ml/min.
The analysis of the data related to the multiple renal diseases patients, showed that most
of the renal diseases were males and representing 57.04% relative to female.
These multi renal diseases patients have predominant mean of GFR as 36.9 ml/min, while
the age group of 20-30, 30-40 and 40-50 year old i.e. young adult having high average
GFR at 43.27 ml/min and the other ages group having decreasing stepwise in GFR to be
ended at the minimum GFR 33.4 ml/min and generally the results shows that the GFR
fluctuating as high in the range of 40s ml/min then decrease with the age increment.
The analyzed data also reveals that the maximum mean of GFR among multi renal
diseases patients is 64.8 ml/min, which is found among the weight group of 110-120 Kg
and the minimum GFR was 24 ml/min among the weight group of 20-30 Kg while the
predominant mean of GFR was 43.2 ml/min among the weight group of 50-60 Kg.
Generally the data showed that as the weight increase the GFR increases and this relation
was expresses by the following equation: GFR 3.14w 25.1 where w refer to weight of
the patient.
The height of the patients also has a direct proportional relation with GFR which follows
the following equation: GFR 3.75h 22.31 where h refer to the height of the patient.