SUST Repository

Development and Validation of HPLC Analytical Assay Method for Mefenamic Acid Suspension

Show simple item record

dc.contributor.author Jadain, Motasim Jadain Alradi
dc.contributor.author Supervisor, -Kamal Mohammed Saeed Fadul
dc.date.accessioned 2020-10-18T08:57:20Z
dc.date.available 2020-10-18T08:57:20Z
dc.date.issued 2019-11-14
dc.identifier.citation Jadain, Motasim Jadain Alradi . Development and Validation of HPLC Analytical Assay Method for Mefenamic Acid Suspension \ Motasim Jadain Alradi Jadain ; Kamal Mohammed Saeed Fadul .- Khartoum:Sudan University of Science and Technology,College of Science,2019.- 87 p.:ill.;28cm.-M.Sc. en_US
dc.identifier.uri http://repository.sustech.edu/handle/123456789/25200
dc.description Thesis en_US
dc.description.abstract Mefenamic acid is analgesic and anti-pyretic used to treat menstrual pain. Asimple assay method by HPLC was developed and validated for mefenamic acid suspension analyses of mefenamic acid in a commercial suspension were performed using HPLC- UV-visble at 254 nm on a reverse phase column Chromolith (RP-18e, 250 mm x 4.6 mm, 5 μm), atertiary mobile phase; Acetonitril: buffer: tetrahydrofurane (40:46:14). The validation aspects were: selectivity, linearity, precision, accuracy and quantification limit. Linearity,20-60 mg\100ml, provided determination coefficients (R of 0.9995, and proved precise since the RSD% was less than 5% for three replicatie analysis. The recoveries obtained ranged from 99% to 108%. In this study, the optimization of mobile phase, flow rate, volume injection and wavelength were achieved through a statistical treatment. The retention time and drug content of mefenamic acid was 10.8 min and 98%, respectively. This method is precise, accurate and very simple to analysis mefenamic acid in suspension. en_US
dc.description.sponsorship Sudan University of Science & Technology en_US
dc.language.iso en en_US
dc.publisher Sudan University of Science and Technology en_US
dc.subject Science en_US
dc.subject Chemistry en_US
dc.subject Validation of HPLC Analytical Assay Method en_US
dc.subject Mefenamic Acid Suspension en_US
dc.title Development and Validation of HPLC Analytical Assay Method for Mefenamic Acid Suspension en_US
dc.title.alternative تطوير وتحقق من طريقة تحليل معلق حمض الميفيناميك بواسطة كروماتوغرافيا السائل ذو الاداء العالي en_US
dc.type Thesis en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Share

Search DSpace


Browse

My Account