Abstract:
This is a descriptive hospital base study aimed to determine the
expression of estrogen and progesterone receptors in breast cancer females
in Khartoum state.
The study was carried out in Khartoum state during the period
between Jan 2008 Jan 2009.
Fifty archived specimens of embedded paraffin wax block were
collected from histopathology lab of Ribat hospital and directorate of
labrotaries and the essential data was collected from patient form.
The disease was distributed in tree group of age women less than 30
Years were (4%) ,women between 30-50years were (43%) and women over
50 years were (53%), Ductal carcinoma is the most distributed type of breast
cancer among the study group (74%).
After applying imunohistochemstry technique using avidin biotin
method the results showed that out of (37) women having ductal carcinoma
with ER positive are 10(20%) whereas carcinoma with ER negative is
27(54%). While out of (13) with non- ductal carcinoma with the expression
of ER positive are 12 (24%) and those with non- ductal carcinoma and ER
negative are 1 (2%).with significant correlation between types of breast
cancer and expression of ER receptors P. value <o.o1.
Females having
ductal carcinoma and positive expression of PR
receptor were 10 (20%), ductal carcinoma and negative expression of PR
receptor were 27(54%), non-ductal carcinoma and positive expression of PR
receptor were 3(6%) and non-ductal carcinomas negative expression were
PR receptor were 10(20%) With significant correlation between type of
breast cancer and expression of PR receptor, P. value <0.01.
The incidence of ER/PR subtypes among the study group showed
(ER+/PR+)were 24% those having( ER+/PR- )were 12%. Those having
(ER-/PR+) were 4%,those having (ER-/PR-)were high incidence shows
60%.
The study showed that there is no significant correlation between age
and type of cancer also between age and expression of ER and PR receptors.
The study recommended more effort for breast cancer were needed,
also large sample size to determine the expression of ER and PR receptors
among breast cancer.
Appling the immunohistochemestry investigation for (ER-/PR-)
negative receptors as routine test to help diagnosis , treatment by hormonal
therapy and prognosis.