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The Role of Ultrasound Versus Total and Free Prostate Specific Antigen in Diagnosis of Benign and Malignant Tumors of Prostate gland

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dc.contributor.author Awad Allah, Babiker Abd Elwahab
dc.contributor.author Supervisor - Bushra Hussein Ahmed
dc.date.accessioned 2013-11-06T10:26:03Z
dc.date.available 2013-11-06T10:26:03Z
dc.date.issued 2009-09-01
dc.identifier.citation Awad Allah,Babiker Abd Elwahab. The Role of Ultrasound Versus Total and Free Prostate Specific Antigen in Diagnosis of Benign and Malignant Tumors of Prostate gland /Babiker Abd Elwahab Awad Allah; Bushra Hussein Ahmed.- Khartoum : sudan university of science and technology,Medical RadiologicScience,2009.- 112p . : ill . ;24cm.- M.Sc. en_US
dc.identifier.uri http://repository.sustech.edu/handle/123456789/2100
dc.description Thesis en_US
dc.description.abstract This is a scientific and practical study which was done during July-2007 to September 2009 and was carried out in Sudan-Khartoum( Khartoum, Omdurman teaching hospitals and college of Medical Radiologic Sciences), and AlGazeera (Alti village – about 78 Km from Khartoum) states. The study discusses the evaluation of U/S Scanning and fPSA in diagnosing of the prostate disorders and differentiation between ca prostate and BPH, also to compare these tools to tPSA. A total of “100” patients were selected randomly; all those patients have age above forty years, have signs of prostatic disorders and referred by physician. Any patient has urinary tract infection or has age less than forty was excluded from this study. All patients were subjected to be examined by U/S scanning using ‘Honda’ Aloka and General Electric scanners with 3,5MHz probe and laboratory investigations which including (tPSA, fPSA and histopathology). Trans abdominal Scanning were performed for all patients and measured AP, transverse, thickness and volume of the prostate, then evaluates the shape and texture of the prostate, then measured their tPSA, fPSA and finally histopathology was done for all patients. The author use Ultrasound findings score in this study; in which any finding in diameters, volume, shape and texture of the prostate, gave specific degree and sum the score of any patient with prostate cancer, to show the less score in which the patient should have prostate carcinoma. Also for data analysis the author uses the crsstabulation, linear regregation and discriminant analysis. This study found that there were 20 patients (20%) have cancer, 78 patients (78%) have BPH, and two patients (2%) have inflammatory changes. Also it found that the age is a risk factor for prostatic disorders. Study revealed that the tPSA is not reliable and accurate in diagnosis of prostatic disorders, U/S scanning and fPSA are more accurate in diagnosis and differentiation between prostatic disorders than tPSA. The study showed that 18 patients (90%) out of 20 cases with prostate carcinoma recorded tPSA more than 10ng/ml, fPSA more than 2ng/ml and fPSA/tPSA ratio less than 1/4.This means that decreasing of fPSA increasing the probability of cancer and increasing of fPSA increasing the probability of BPH "the cancer increased the bound PSA with α - Antichemotrypsin protein ,while the BPH increased the free PSA in blood. In addition to that the study shows that; the U/S findings of the prostate cancer mostly changes shape 7 patients (35%) out of 20 cases with cancer, or changed texture with presence of nodule 19 patients (95%), which may be present in centre or peripheral of prostate (Abnormal shape or abnormal texture) with transverse diameter of prostate is greater than AP diameter of prostate. By using linear and discriminant analysis study found that there were three equations by which, we could predict the type of disease in any case (Ca, BPH or inflammation) by using tPSA, fPSA and U/S features (AP, transeverse, thickness, shape, and texture of prostate), this means that; no one of these three tools (t PSA, fPSA and U/S scanning) can determined the type of disease alone if it is Ca or BPH accurately 100%. This study recommended that any man has age greater than fifty years or has high sexual activity should be scanned by U/S routinely to exclude the presence of prostatic disease, because U/S is cheep ,safety, and reliable than tPSA. en_US
dc.description.sponsorship sudan university of science and Technology en_US
dc.language.iso en en_US
dc.publisher sudan university of science and technology en_US
dc.subject prostate en_US
dc.subject diseases en_US
dc.title The Role of Ultrasound Versus Total and Free Prostate Specific Antigen in Diagnosis of Benign and Malignant Tumors of Prostate gland en_US
dc.type Thesis en_US


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