Abstract:
A case control study was conducted during the period from April to
October 2012 to assess serum levels of thyrotropin(TSH) and thyroxineT4 among
sudanese patients with type2 diabetes mellitus. Fifty patients with type2
diabetes mellitus were selected as a test group from the Khartoum
Teaching Hospital and Zenam Hospital in Khartoum state ,Sudan. The
test group was compared with a control group which included 40
apparently healthy volunteers. Blood specimens were collected from
both
groups and
fasting blood glucose,
glycated hemoglobin,
thyrotropin and thyroxine were estimated.
Age and gender of the test group were matched with the control
group. Spectrophotometeric methods were used for measurement of
glucose.
Glycated
hemoglobin
was
measured
by
using
chromatographic- spectrophotometric ionexchange method and the
thyrotropin and thyroxine measured by Electrochemiluminescent method.
Statistical package for social science (SPSS version 11.5) computer
software was used for data analysis. The results of this study
indicated a significant decrease in the mean of serum levels of
thyroxine in test group compared with the control subjects and
insignificant deference in the mean of serum levels of thyrotropin.
Also there was insignificant deference in the mean of serum levels of thyrotropin and thyroxine in diabetic males compared to diabetic
2females. There was no correlation between thyrotropin in type
diabetic patient and fasting blood glucose, glycated hemoglobin and
body mass index. Also there was negative correlation between
thyroxine in type2 diabetic patient and fasting blood glucose; and no
correlation between thyroxine in type2 diabetic patient and glycated
.hemoglobin and body mass index