Abstract:
In this work, dihydropyrimidinone and their sulphur analogue dihydropyrimidinthione derivatives were synthesized by green chemistry approach in order to simplify and improve conditions that has been used
traditionally to carry out the conventional Biginelli reaction for the synthesis of
these derivatives.
These reactions were performed by three-component condensation of different
types of an aldehyde, ethyl acetoacetate, and urea or thiourea at reflux temperature under solvent-free conditions without catalyst to afford the corresponding dihydropyrimidinones and dihydropyrimidinthione in excellent
yields(76–96%). Chapter one of this thesis deals basically with the green chemistry, the principles of green chemistry, green technologies. This chapter deals also with dihydropyrimidinone and dihydropyrimidinthione derivatives
together with a review of their biological importance.
In this work 10 dihydropyrimidinone and dihydropyrimidinthione derivatives
were synthesized. The reaction course was followed by m.p and TLC technique.
All the final products were subjected to UV and IR analysis. Furthermore, products were analyzed with GCMS and 1HNMR. Possible mechanistic explanation of the synthetic route together with their retrosynthetic analysis were dealt with in chapter three.