dc.contributor.author |
Mohammed, Kawther Mirghani |
|
dc.date.accessioned |
2015-11-18T08:29:14Z |
|
dc.date.available |
2015-11-18T08:29:14Z |
|
dc.date.issued |
2015-08-01 |
|
dc.identifier.citation |
Mohammed,Kawther Mirghani . Synthesis of Some 2-sulphanilamido-1,4-Quinone Derivatives \ Kawther Mirghani Mohammed ; Ahmed Elsadig Mohammed Saeed .- Khartoum : Sudan University of Science and Technology , College of Science , 2015 .- 142 p. :ill. ;28cm .-M.Sc. |
en_US |
dc.identifier.uri |
http://repository.sustech.edu/handle/123456789/11922 |
|
dc.description |
Thesis |
en_US |
dc.description.abstract |
Ten new 2-sulfonilamido-1, 4-quinone derivatives were prepared in this work with
their corresponding intermediates which include five p-aminobenzene
sulphonilamido derivatives and two 1,4-quinone derivatives. Synthesis of the titled
compounds was accomplished by chlorosulphonation of acetanilide and amination
(sulfamethoxzole, 4-aminophenazone, sulfadoxine, sulphonilamide and sulfasulph
onilamide) to furnish the p-acetamedobenzene sulphonilamido derivatives, the
latter upon acid hydrolysis yielded p-amino benzene sulphonilamido derivatives.
1,4- quinone (1,4-naphthoquinone and 2-methyl-1,4-benzoquinoe were prepared
by standard methods of chromic acid oxidation of naphthalene and o-crezol
respectively. Coupling of the aminobenzene sulphonil amido derivative with 1,4-
quinone moiety furnished the titled product. All synthesized compounds checked
their reaction progress by (TLC) techniques. The structures of synthesized
compounds were confirmed by some physical properties; (melting point) and
spectroscopic analysis like (IR, 1H-NMR, 13C-NMR and MS).Synthetic designing
and mechanisms of the reactions of the different groups of compounds were
discussed. |
en_US |
dc.description.sponsorship |
SUDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Sudan University of Science and Technology |
en_US |
dc.subject |
Synthesis |
en_US |
dc.subject |
sulphanilamido |
en_US |
dc.subject |
Quinone Derivatives |
en_US |
dc.title |
Synthesis of Some 2-sulphanilamido-1,4-Quinone Derivatives |
en_US |
dc.title.alternative |
تخلیق بعض مشتقات 2- سلفونیل امیدو- 4،1 - كینون |
en_US |
dc.type |
Thesis |
en_US |